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Join RedTube Premium and never look back. Jonathan Karn of Case Western Reserve University, found that women have a smaller "inducible" reservoir than men.

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In other words, while the total size of Milk April ONeil reservoir appears to be the same for both sexes, women have a smaller amount of reservoir virus that can be coaxed out of hiding by so-called latency-reversing agents LRAs.

The finding has several important implications.

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First, one of the main cure strategies being pursued by researchers is "shock and Milk April ONeil or "kick and kill". The intent is to shock HIV out of the reservoir so that it can be killed by the immune system or some other killing agent.

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Given their smaller inducible reservoir, would such a strategy be less effective in women? Second, since reactivation of the reservoir is inhibited by estrogen, the researchers suggest that "studies of the impact of hormonal contraception on reservoir establishment and its Milk April ONeil maintenance should be undertaken.

And, given the small size and exploratory nature of cure-focused clinical studies to date, the inclusion of women in small clinical trials may lead to skewed results if hormone exposure is not considered. The study concludes that further investigations into sex differences in Milk April ONeil reversal and HIV persistence "are mandatory to extend the benefits of the HIV cure effort to all men and women impacted by Milk April ONeil global epidemic.

Published in the Proceedings of the National Academy of Sciencesthese findings are the most recent outgrowth dreams of desire a multi-year amfAR investigation into sex differences in HIV.

Rowena Johnston, a co-author of the study.

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